GABRG2 Antibody | 399-CSB-PA288970

Code:

CSB-PA288970

Uniprot No.:

P18507

Target Names:

GABRG2

Alternative Names:

CAE 2 antibody; CAE2 antibody; ECA 2 antibody; ECA2 antibody; GABA(A) receptor gamma 2 antibody; GABA(A) receptor subunit gamma 2 antibody; GABA(A) receptor subunit gamma-2 antibody; GABRG 2 antibody; GABRG2 antibody; Gamma aminobutyric acid (GABA) A receptor gamma 2 antibody; Gamma aminobutyric acid A receptor gamma 2 antibody; Gamma aminobutyric acid receptor gamma 2 subunit antibody; Gamma-aminobutyric acid receptor subunit gamma-2 antibody; GBRG2_HUMAN antibody; GEFSP 3 antibody; GEFSP3 antibody

Raised in:

Rabbit

Species Reactivity:

Human, Mouse, Rat

Immunogen:

Synthetic Peptide

Immunogen Species:

Homo sapiens (Human)

Conjugate:

Non-conjugated

Purification Method:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.

Concentration:

It differs from different batches. Please contact us to confirm it.

Buffer:

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form:

Liquid

Tested Applications:

WB, IHC, ELISA

Protocols:

• Western Blotting(WB) Protocol
• Immunohistochemistry (IHC) Protocol
• ELISA Protocol

Troubleshooting and FAQs:

Antibody FAQs

Storage :

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time:

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Function:

Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity. The alpha2/beta2/gamma2 receptor exhibits synatogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity. Functions also as histamine receptor and mediates cellular responses to histamine.

Involvement in disease:

Epilepsy, childhood absence 2 (ECA2); Febrile seizures, familial, 8 (FEB8); Generalized epilepsy with febrile seizures plus 3 (GEFS+3)

Subcellular Location:

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Cytoplasmic vesicle membrane.

Protein Families:

Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRG2 sub-subfamily